E-ISSN 2455-3166
 

Original Research 


Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats

Chandrashekhar Y Jagtap, Mukesh B Nariya, Vinay J Shukla, Pradeep Kumar Prajapati.

Abstract
Background: The lipid lowering activity of herbs plays an important role in the reduction of cardiovascular diseases (CVDs); where there is relation between low density lipoprotein (LDL) reduction and decreased CVD mortality. Consequently, medicinal plant lipid lowering activity for phyto-medicine research and drug development for such a disease are now focused all over the world. Hridayarnava Rasa (HR) is herbo-mineral formulation told in the classics for the treatment of Hridroga (cardiac diseases). Ingredients of this formulation like Tamra Bhasma (incinerated copper), Triphala Kwatha (decoction of three myrobalans) and juice of Solanum nigrum Linn. are proven antihyperlipidemic.

Aim: In present study, antihyperlipidemic activity of HR prepared from two samples of Tamra Bhasma (Shodhita and Ashodhita) is carried out to assess the impact of Shodhana procedure on efficacy of whole formulation.

Materials and methods: STBHR (HR prepared from Shodhita Tamra Bhasma) and ATBHR (HR prepared from Ashodhita Tamra Bhasma) were prepared as per the classical references. Hyperlipidemia was induced by feeding high fat diet in Wistar strain albino rats. The parameters including body weight, weight of various organs, serum lipid profile and histopathology of liver, kidney, heart and aorta were studied. Statistical analysis used: Statistical comparisons were performed by both unpaired student’s t test and one way ANOVA with Dunnets’ multiple t test as post-hoc test by using Sigma stat software (version 3.1) for all the treated groups. P value less than 0.05 were considered as significant.

Results: Treatment with STBHR attenuated serum cholesterol and triglyceride but not to the significant extent, while treatment with ATBHR failed to attenuate any lipid profile. STBHR also attenuated the hyperlipidemic diet induced pathological changes whereas ATBHR failed to do so.

Conclusion: Hridayarnava Rasa prepared from Shodhita Tamra Bhasma shows mild antihyperlipidemic activity whereas the same prepared from Ashodhita Tamra Bhasma lacks it.

Key words: Bhasma, Copper, Hyperlipidemia, Mercury, Solanum nigrum Linn., Triphala.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Chandrashekhar Y Jagtap
Articles by Mukesh B Nariya
Articles by Vinay J Shukla
Articles by Pradeep Kumar Prajapati
on Google
on Google Scholar
Article Statistics
 Viewed: 807
Downloaded: 17
Cited: 0

How to Cite this Article
Pubmed Style

Jagtap CY, Nariya MB, Shukla VJ, Prajapati PK. Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. J. res. tradit. med. 2018; 4(3 - 4): 88-96. doi:10.5455/jrtm.2018/2112


Web Style

Jagtap CY, Nariya MB, Shukla VJ, Prajapati PK. Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. http://www.tmjournal.org/?mno=2112 [Access: April 19, 2019]. doi:10.5455/jrtm.2018/2112


AMA (American Medical Association) Style

Jagtap CY, Nariya MB, Shukla VJ, Prajapati PK. Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. J. res. tradit. med. 2018; 4(3 - 4): 88-96. doi:10.5455/jrtm.2018/2112



Vancouver/ICMJE Style

Jagtap CY, Nariya MB, Shukla VJ, Prajapati PK. Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. J. res. tradit. med. (2018), [cited April 19, 2019]; 4(3 - 4): 88-96. doi:10.5455/jrtm.2018/2112



Harvard Style

Jagtap, C. Y., Nariya, . M. B., Shukla, . V. J. & Prajapati, . P. K. (2018) Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. J. res. tradit. med, 4 (3 - 4), 88-96. doi:10.5455/jrtm.2018/2112



Turabian Style

Jagtap, Chandrashekhar Y, Mukesh B Nariya, Vinay J Shukla, and Pradeep Kumar Prajapati. 2018. Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 4 (3 - 4), 88-96. doi:10.5455/jrtm.2018/2112



Chicago Style

Jagtap, Chandrashekhar Y, Mukesh B Nariya, Vinay J Shukla, and Pradeep Kumar Prajapati. "Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 4 (2018), 88-96. doi:10.5455/jrtm.2018/2112



MLA (The Modern Language Association) Style

Jagtap, Chandrashekhar Y, Mukesh B Nariya, Vinay J Shukla, and Pradeep Kumar Prajapati. "Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 4.3 - 4 (2018), 88-96. Print. doi:10.5455/jrtm.2018/2112



APA (American Psychological Association) Style

Jagtap, C. Y., Nariya, . M. B., Shukla, . V. J. & Prajapati, . P. K. (2018) Comparative antihyperlipidemic activity of Hridayarnava Rasa prepared from two samples of Tamra Bhasma in Wistar albino rats. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 4 (3 - 4), 88-96. doi:10.5455/jrtm.2018/2112





Most Viewed Articles
  • Efficacy of Erand Sneha (Castor Oil) in the management of Amavata (Rheumatoid arthritis) with respect to its Sama Stage
    Gauridutt Mishra *, Darshana H Pandya
    J. res. tradit. med. 2017; 3(2): 28-35
    » Abstract

  • URAMARUNNU - A TRADITIONAL AYURVEDIC PAEDIATRIC PRACTICE
    INDU SABU, KRISHNA RAO SATHYA
    J. res. tradit. med. 2017; 3(3): 91-97
    » Abstract

  • Shashti Upakrama (Sixty Procedures) in the management of Vrana (Wound) - A Review
    Rajneesh V Giri
    J. res. tradit. med. 2017; 3(4): 109-116
    » Abstract

  • Concept of Chakshushya in the Materia Medica of Ayurveda
    Tarkeshwar Sukhadev Wankhade* , Pravin Raghunathrao Joshi, Suraj Laxmansingh Thakur, Mante G B
    J. res. tradit. med. 2017; 3(2): 55-63
    » Abstract

  • Pharmaceutico - Analytical Study of Shrugatakadi Taila using the concept of Taila Murchhana (Oil Processing)
    Juhi Ubale* , Anita Wanjari, Bharath Rathi, Dhirajsingh Rajput
    J. res. tradit. med. 2017; 3(2): 36-42
    » Abstract

  • Histological validation of Pleeha (Spleen) as one of the Mulasthana (Origin) of Rakta Vaha Srotas (Circulatory System)
    Gaurav Soni*, Neelam
    J. res. tradit. med. 2017; 3(1): 18-22
    » Abstract

  • Pharmaceutical Standardisation of Kukkutanda Tvak Bhasma (Incinerated Egg Shell)
    Ghanshyam Mahulkar * , Bharat Rathi
    J. res. tradit. med. 2017; 3(2): 43-50
    » Abstract

  • Indigenous knowledge of medicinal plants and perception of managing disease among the Yanadi Tribe of Veyi Lingala Kona
    Chandrika Thalari*, Palapandala Thiripalu
    J. res. tradit. med. 2017; 3(1): 12-17
    » Abstract

  • The ‘four’ stratagem of Traditional Indian Medicine – Ayurveda
    Jyothy Kothanath Bhaskaran
    J. res. tradit. med. 2017; 3(4): 98-100
    » Abstract

  • Review on Various types of Makaradhwaja (Gold containing mercurial preparation)
    Mangala Jadhav *, Swati S Chirane, Anjali Menon
    J. res. tradit. med. 2017; 3(2): 51-54
    » Abstract

  • Most Downloaded
  • URAMARUNNU - A TRADITIONAL AYURVEDIC PAEDIATRIC PRACTICE
    INDU SABU, KRISHNA RAO SATHYA
    J. res. tradit. med. 2017; 3(3): 91-97
    » Abstract

  • A Review on Smriti (Memory) and its Affiliates in Ayurveda
    Pallavi Ashok Ghadage, Niranjan Yethdaka, Narendra Trivedi
    J. res. tradit. med. 2017; 3(5): 143-150
    » Abstract

  • Prevention & Management of Autism – An Ayurvedic Perspective
    Brahm Dutt Sharma*, Khushal Chouhan
    J. res. tradit. med. 2016; 2(4): 117-121
    » Abstract

  • Early Clinical Diagnosis of Fever (Jwara) in Children – A Case Study
    Jyothy Kothanath Bhaskaran*, Srihari Sheshagiri
    J. res. tradit. med. 2016; 2(6): 170-172
    » Abstract

  • Evaluation of Anti - Hyperglycaemic activity of Madhu (Honey) in High fat diet induced diabetes - An Experimental study
    Sowmya Hariharapura Yogendra, Satish Pai, Manjula Santhepete Nanjundayya
    J. res. tradit. med. 2017; 3(5): 129-136
    » Abstract

  • Anti-obesity and Anti-hyperlipidemic activity of Processed Honey - A Randomised, Open labeled, Controlled Clinical Study [English]
    Satish Pai, Chetana Bhadrapura Shivappa, Aparna Surendra
    J. res. tradit. med. 2018; 4(2): 40-48
    » Abstract » doi: 10.5455/JRTM.2018/816

  • Demographic Survey of Traditional healers and their practices in Ikorodu and Mushin Local government areas of Lagos State, Nigeria
    Glory Oluremilekun Ajayi, Rashidat Salami, Iranlowo Omonijo
    J. res. tradit. med. 2018; 4(1): 1-8
    » Abstract » doi: 10.5455/JRTM.2018/291584

  • Concept of Chakshushya in the Materia Medica of Ayurveda
    Tarkeshwar Sukhadev Wankhade* , Pravin Raghunathrao Joshi, Suraj Laxmansingh Thakur, Mante G B
    J. res. tradit. med. 2017; 3(2): 55-63
    » Abstract

  • Application of Tantrayukti (Means of Interpreting Science) in Research Methodology
    Anil D. Avhad*, Manjiri Walinjkar, Hitesh A. Vyas, R.R. Dwivedi
    J. res. tradit. med. 2016; 2(3): 81-86
    » Abstract

  • Shashti Upakrama (Sixty Procedures) in the management of Vrana (Wound) - A Review
    Rajneesh V Giri
    J. res. tradit. med. 2017; 3(4): 109-116
    » Abstract

  • Most Cited Articles
  • Literature Review of Suram(Fever) in Siddha Medicine
    Thayalini Thileepan
    J. res. tradit. med. 2018; 4(1): 21-25
    » Abstract » doi: 10.5455/JRTM.2018/298118
    Cited : 1 time [Click to see citing article]

  • Fourier Transforms Infrared Spectroscopy Study on Shadguna Makaradhwaja - An Ayurvedic Mercurial Drug Compound
    Vaibhav Charde*, Kishor Patel, Rohit Gokarn, Dhirajsingh Rajput, Biswajyoti Patgiri, Pradeep Kumar Prajapati
    J. res. tradit. med. 2016; 2(4): 94-98
    » Abstract
    Cited : 1 time [Click to see citing article]