Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial

Sana Hasan; Iram Naaz; Mohd Shahid; Mohd Aleemuddin Quamri

doi:10.5455/jrtm.2026-312156

J. res. tradit. med. 2026; 12(1): 128-139

doi: 10.5455/jrtm.2026-312156

Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial

Sana Hasan, Iram Naaz, Mohd. Shahid, Mohd. Aleemuddin Quamri.

Abstract
Background: Tinea corporis is a highly prevalent superficial fungal infection of the skin that poses a considerable burden on society. Although effective, modern therapeutic options are increasingly associated with the development of drug resistance and various adverse effects such as hepatotoxicity and phototoxicity. In this context, Unani therapy may serve as a safe and effective alternative. Objective: To evaluate and compare the efficacy of two polyherbal Unani Zemads (PUZ-1) and PUZ-2 with Joshanda Haleela Siyah (JHS) in the management of T. corporis. Methods: A randomised, single-blind, comparative clinical trial was conducted among 40 patients aged 18-60 years diagnosed with T. corporis infection. Participants were divided into two groups. Group A participants received JHS (15 g once daily) along with PUZ-1 (once daily local application for 10 min). Group B received the same oral formulation with topical PUZ-2. The intervention was administered for 3 weeks, with weekly follow-up assessments. Treatment efficacy was evaluated using the global assessment scale, KOH examination, and photographs of the lesion. The trial was approved by the Institutional Ethical Committee (NIUM/IEC/2021-22/031/JT/06,) and registered in Clinical Trial Registry of India (CTRI/2023/06/053844). Results: Both groups demonstrated a statistically significant reduction from the baseline in all outcome measures (p < 0.001). Although the intergroup differences were not statistically significant (p>0.05), group A showed comparatively better clinical improvement in terms of pruritus reduction. Conclusion: Both PUZ ointments and JHS were effective in the management of T. corporis, resulting in a significant reduction in all the outcome measures. However, JHS with PUZ-1 demonstrated a relatively faster response to pruritus reduction.

Key words: Polyherbal Unani Zemad, Pruritus, Qooba, Tinea corporis, Unani Medicine

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How to Cite this Article

Pubmed Style

Hasan S, Naaz I, Shahid M, Quamri MA. Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. J. res. tradit. med. 2026; 12(1): 128-139. doi:10.5455/jrtm.2026-312156

Web Style

Hasan S, Naaz I, Shahid M, Quamri MA. Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. https://www.tmjournal.org/?mno=312156 [Access: July 27, 2026]. doi:10.5455/jrtm.2026-312156

AMA (American Medical Association) Style

Hasan S, Naaz I, Shahid M, Quamri MA. Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. J. res. tradit. med. 2026; 12(1): 128-139. doi:10.5455/jrtm.2026-312156

Vancouver/ICMJE Style

Hasan S, Naaz I, Shahid M, Quamri MA. Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. J. res. tradit. med. (2026), [cited July 27, 2026]; 12(1): 128-139. doi:10.5455/jrtm.2026-312156

Harvard Style

Hasan, S., Naaz, . I., Shahid, . M. & Quamri, . M. A. (2026) Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. J. res. tradit. med, 12 (1), 128-139. doi:10.5455/jrtm.2026-312156

Turabian Style

Hasan, Sana, Iram Naaz, Mohd. Shahid, and Mohd. Aleemuddin Quamri. 2026. Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 12 (1), 128-139. doi:10.5455/jrtm.2026-312156

Chicago Style

Hasan, Sana, Iram Naaz, Mohd. Shahid, and Mohd. Aleemuddin Quamri. "Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 12 (2026), 128-139. doi:10.5455/jrtm.2026-312156

MLA (The Modern Language Association) Style

Hasan, Sana, Iram Naaz, Mohd. Shahid, and Mohd. Aleemuddin Quamri. "Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 12.1 (2026), 128-139. Print. doi:10.5455/jrtm.2026-312156

APA (American Psychological Association) Style

Hasan, S., Naaz, . I., Shahid, . M. & Quamri, . M. A. (2026) Therapeutic efficacy of two polyherbal Unani formulation in the treatment of Tinea corporis infection: A randomised, single-blind, comparative clinical trial. JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE, 12 (1), 128-139. doi:10.5455/jrtm.2026-312156